Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient
Identifieur interne : 002D22 ( Main/Exploration ); précédent : 002D21; suivant : 002D23Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient
Auteurs : Katie Kompoliti [États-Unis] ; Yaping Chu [États-Unis] ; Kathleen M. Shannon [États-Unis] ; Jeffrey H. Kordower [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-08-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adrenal Medulla (cytology), Adrenal Medulla (transplantation), Autologous system, Autopsy (methods), Brain (pathology), Brain (surgery), Cell Survival (physiology), Chromogranin A (metabolism), Dopamine, Female, Human, Humans, Longitudinal Studies, Middle Aged, Nerve Tissue Proteins (metabolism), Nervous system diseases, Parkinson, Parkinson Disease (pathology), Parkinson Disease (surgery), Parkinson disease, Time Factors, Transplantation, Transplantation, Autologous (methods), Tyrosine 3-Monooxygenase (metabolism), adrenal transplant, brain transplant, chromaffin, dopamine.
- MESH :
- chemical , metabolism : Chromogranin A, Nerve Tissue Proteins, Tyrosine 3-Monooxygenase.
- cytology : Adrenal Medulla.
- methods : Autopsy, Transplantation, Autologous.
- pathology : Brain, Parkinson Disease.
- physiology : Cell Survival.
- surgery : Brain, Parkinson Disease.
- transplantation : Adrenal Medulla.
- Female, Humans, Longitudinal Studies, Middle Aged, Time Factors.
Abstract
To date, there is no clinicopathological correlation of adrenal medullary transplant cases in patients with survival beyond a few years. Postmortem examination of a brain from a patient with Parkinson's disease (PD), 16 years after autologous adrenal medullary transplant, was performed using tyrosine hydroxylase (TH) and chromogranin A. The patient experienced a four‐year initial improvement in motor function followed by resumption of the progressive nature of her disease that continued until her death. She expired 16 years following grafting. At autopsy, TH stain of the brain revealed severe loss of TH‐immunoreactivity in the substantia nigra and Lewy bodies, confirming the diagnosis of PD. The transplant site was identified by the presence of scarring and there was complete absence of any TH staining cells at the site of the transplant. There were few surviving cells staining with chromogranin A. The absence of TH‐staining cells in the transplant 16 years after surgery provides further evidence that adrenal medullary transplants do not survive in the long term. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21528
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002B03
- to stream Istex, to step Curation: 002B03
- to stream Istex, to step Checkpoint: 001830
- to stream PubMed, to step Corpus: 002680
- to stream PubMed, to step Curation: 002680
- to stream PubMed, to step Checkpoint: 002694
- to stream Ncbi, to step Merge: 001C59
- to stream Ncbi, to step Curation: 001C59
- to stream Ncbi, to step Checkpoint: 001C59
- to stream Main, to step Merge: 003C44
- to stream PascalFrancis, to step Corpus: 001560
- to stream PascalFrancis, to step Curation: 001761
- to stream PascalFrancis, to step Checkpoint: 001569
- to stream Main, to step Merge: 004159
- to stream Main, to step Curation: 002D22
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient</title><author><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name></author><author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name></author><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:584018BB5E89F112395CBB53A47378A43A3F8340</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21528</idno><idno type="url">https://api.istex.fr/document/584018BB5E89F112395CBB53A47378A43A3F8340/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002B03</idno><idno type="wicri:Area/Istex/Curation">002B03</idno><idno type="wicri:Area/Istex/Checkpoint">001830</idno><idno type="wicri:doubleKey">0885-3185:2007:Kompoliti K:neuropathological:study:years</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:17534949</idno><idno type="wicri:Area/PubMed/Corpus">002680</idno><idno type="wicri:Area/PubMed/Curation">002680</idno><idno type="wicri:Area/PubMed/Checkpoint">002694</idno><idno type="wicri:Area/Ncbi/Merge">001C59</idno><idno type="wicri:Area/Ncbi/Curation">001C59</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C59</idno><idno type="wicri:doubleKey">0885-3185:2007:Kompoliti K:neuropathological:study:years</idno><idno type="wicri:Area/Main/Merge">003C44</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:07-0448800</idno><idno type="wicri:Area/PascalFrancis/Corpus">001560</idno><idno type="wicri:Area/PascalFrancis/Curation">001761</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001569</idno><idno type="wicri:doubleKey">0885-3185:2007:Kompoliti K:neuropathological:study:years</idno><idno type="wicri:Area/Main/Merge">004159</idno><idno type="wicri:Area/Main/Curation">002D22</idno><idno type="wicri:Area/Main/Exploration">002D22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient</title><author><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-08-15">2007-08-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1630">1630</biblScope><biblScope unit="page" to="1633">1633</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">584018BB5E89F112395CBB53A47378A43A3F8340</idno><idno type="DOI">10.1002/mds.21528</idno><idno type="ArticleID">MDS21528</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Medulla (cytology)</term><term>Adrenal Medulla (transplantation)</term><term>Autologous system</term><term>Autopsy (methods)</term><term>Brain (pathology)</term><term>Brain (surgery)</term><term>Cell Survival (physiology)</term><term>Chromogranin A (metabolism)</term><term>Dopamine</term><term>Female</term><term>Human</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term><term>Nerve Tissue Proteins (metabolism)</term><term>Nervous system diseases</term><term>Parkinson</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (surgery)</term><term>Parkinson disease</term><term>Time Factors</term><term>Transplantation</term><term>Transplantation, Autologous (methods)</term><term>Tyrosine 3-Monooxygenase (metabolism)</term><term>adrenal transplant</term><term>brain transplant</term><term>chromaffin</term><term>dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chromogranin A</term><term>Nerve Tissue Proteins</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Adrenal Medulla</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Autopsy</term><term>Transplantation, Autologous</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Survival</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Adrenal Medulla</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Homme</term><term>Parkinson maladie</term><term>Système autologue</term><term>Système nerveux pathologie</term><term>Transplantation</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To date, there is no clinicopathological correlation of adrenal medullary transplant cases in patients with survival beyond a few years. Postmortem examination of a brain from a patient with Parkinson's disease (PD), 16 years after autologous adrenal medullary transplant, was performed using tyrosine hydroxylase (TH) and chromogranin A. The patient experienced a four‐year initial improvement in motor function followed by resumption of the progressive nature of her disease that continued until her death. She expired 16 years following grafting. At autopsy, TH stain of the brain revealed severe loss of TH‐immunoreactivity in the substantia nigra and Lewy bodies, confirming the diagnosis of PD. The transplant site was identified by the presence of scarring and there was complete absence of any TH staining cells at the site of the transplant. There were few surviving cells staining with chromogranin A. The absence of TH‐staining cells in the transplant 16 years after surgery provides further evidence that adrenal medullary transplants do not survive in the long term. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name></region><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D22 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D22 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:584018BB5E89F112395CBB53A47378A43A3F8340
|texte= Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient
}}
| This area was generated with Dilib version V0.6.23. |  |